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KMID : 0613820110210101364
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Journal of Life Science
2011 Volume.21 No. 10 p.1364 ~ p.1369
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Ethyl Acetate Extract of Korean Rice Wine Lees Inhibits IgE-Mediated Degranulation in Rat Basophilic Leukemia RBL-2H3 Cells and Passive Cutaneous Anaphylaxis in Mice
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Kang Yeo-Jin
Park Sae-Jin
Bae Ki-Ho
Yoo Jung-Min
Pyo Hyeong-Bae
Choi Ji-Ho
Kim Tack-Joong
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Abstract
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Mast cells, the central effector cells involved in the allergic response, release histamine, arachidonic acid, and proinflammatory cytokines. We investigated the effect of the ethyl acetate fraction (EA), derived from Korean rice wine lees, on RBL-2H3 cell degranulation and passive cutaneous anaphylaxis in an animal model. The EA fraction suppressed the release of beta-hexosaminidase, a marker of degranulation, and the mRNA expression of interleukin-3 (IL-3) and IL-13. EA also successfully suppressed the passive cutaneous anaphylaxis (PCA) reaction in mice in a dose-dependent manner. These results suggest that EA can inhibit mast cell degranulation through the inhibition of IL-3 and IL-13 mRNA expression, and that EA may potentially serve as an anti-allergic agent.
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KEYWORD
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Korean rice wine lees, mast cells, allergic response, passive cutaneous anaphylaxis
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